Adriana Ackerman, Student Researcher in Chemistry

What are you researching and with whom?

I'm working in a synthetic organic chemistry lab with Professor Michael Krout, we focus on synthesizing natural products in a lab. Specifically we're researching a family of chemicals known as eudesmanes, synthesized in plants which have antibacterial and antifungal properties. For the molecule to function, it has to be in a specific stereo conformation, and thats the tricky part. We need to synthesize the molecule and select for stereochemistry. My specific portion of the project has to do with methodology, and I'm optimizing the reaction. I'm finding the conditions for the reaction to run that maximizes yield and time, or produces the same product using cheaper reagents.

How did you come into this opportunity?

I took Krout's organic chemistry class my freshman year, and was surprised by how much I liked organic chemistry. I attended a summer research presentation where all the faculty presented their research and what they did. As a biochemistry major, I was drawn to Krout's project. I could do chemistry research but it had a biological function; I'm working on projects with implications for pharmaceuticals, agriculture and engineering. I asked Professor Krout if I could join his lab, and I've been working for him since May 2014.

Did you enjoy your summer experience here at Bucknell?

Summer at Bucknell is much quieter than during the year, but I'm able to be in the lab all day. When I do research now, it has to be timed between classes, homework and extracurriculars and I'm not able to devote as much time to research as I'd like. What I can get done in 2 weeks during the year, I can get done in 2 days over the summer. Researching over the summer allows you to make substantial gains on a real project, an invaluable experience for me. Being here over the summer allowed me to explore more of PA than I ever did during the year, and I visited Ard's, OIPS and several hiking paths for the first time. Plus, the gym was never busy and I could always get the treadmills with the fans in them.

Richard Crago, Civil Engineering

What does Discovery mean to you?

Coming up with a hypothesis that you think might work, testing it against data, and finding that it does in fact work. In my research, that’s the nature of discovery. My research deals with estimating evaporation and transpiration from land surfaces using remotely gathered data from satellites. This is very useful for estimating the amount of water available during the growing season. . . My master’s thesis advisor presented the project to me, and I looked into it and found that I was very interested in the subject area. What’s great about research at Bucknell is that we can pick projects of personal interest. Even if we can’t get our research published, we can still work with a student on something we find fascinating.

Pete Brooksbank, Mathematics

Pete Brooksbank

photo from bucknell.edu

 Is there any way you could in laymen’s terms structure one of the algebraic problems you are trying to solve using these really advanced and complicated models?
"Sure. Maybe a good thing to think about is the familiar Rubik’s cube. With the cube, there six different faces that you can rotate, and there are many different configurations that you can generate from these face rotations. Rather amusingly, Ideal Toy, the original manufacturers of the cube, wrote on the packaging that there are more than 3 billion configurations. This sounds like an awful lot, but in fact they underestimated the actual number by a factor of about 10 billion! The challenge, if you’ve ever played with the cube, is to take a scrambled configuration and return it to its original solved state. People who are good at this come up with various "macros" that move the cube from more scrambled to less scrambled states, with each successive state being a better approximation of the solved cube. In this way they are able rather quickly to reach the solved state. Of course, when human beings solve the cube, they are really using a lot of geometric insight and visual recognition. However, you can also think of the cube problem in purely algebraic terms: underlying it is an example of the kind of algebraic problem that I’m interested in. Specifically, you have a couple of fixed symmetries of the cube, namely the face rotations, and you are given a scrambled configuration of the cube. Your job is to unscramble this configuration back to the solved one. The catch is that you don't have a physical cube to work with! All you have is the algebraic description of what these different face rotations are doing. Well, you can in fact program a computer to do this, but it’s not going to produce the optimal solution because you have not told it that there's a cube behind the problem. Thus, the computer cannot have the same geometric intuition as human beings. Rather, it works only with the algebraic structure. Despite this apparent handicap, computer algorithms can solve the cube almost effortlessly using a moderate number of moves. So that’s one type of problem that I'm interested in. It’s an example of a "constructive word problem" for algebraic objects called "groups". There are far more general versions of that problem, and highly refined methods for solving them. As these methods go, the Rubik’s cube problem is child’s play: the computer can solve the cube in the blink of an eye. In my work, I deal with vastly larger algebraic objects whose underlying structure is far more complex than that of the cube."

Chris Martine, Biology

Professor Martine talks about plant biology and gives us a tour of the greenhouse. If you find this interesting, be sure to check out Martine's YouTube series linked at the end of the video!